Craniosynostoses

Oxilorphan

Oxilorphan
Systematic (IUPAC) name
(-)-17-(Cyclopropylmethyl)morphinan-3,14-diol
Identifiers
CAS number 42281-59-4
ATC code  ?
PubChem 5361090
Chemical data
Formula C20H27NO2 
Mol. mass 313.44 g/mol
Synonyms Oxilorphan
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?

Legal status
Routes  ?

Oxilorphan is an opioid antagonist from the morphinan family of drugs.

Oxilorphan is a non-selective opioid which is a %u03BC antagonist but a %u03BA partial agonist. It has similar effects to naloxone, and around the same potency as an antagonist.[1]

Oxilorphan has some weak partial agonist effects[2] and can produce hallucinogenic effects at high doses, suggesting some kappa opioid agonist action.[3] It was trialled for the treatment of opiate addiction, but was not developed commercially.[4]



     


     
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